Histological changes in the rat’s jejunum wall under the conditions of action of common European adder (Vipera berus berus) venom

The numerous components of the venoms various animal species cause an extremely wide range effects and symptoms in recipient’s body. At same time, degree severity pathological changes is determined, general, by type animal, volume method toxin administration, as well characteristic features victim. Changes structural functional parameters wall jejunum under influence viper venom are still poorly understood. Research aimed at identifying new snake toxins, determining their on affected organism using obtained data for production antidotes, thereby eliminating economic losses associated with bites, should be considered relevant. purpose study to establish manifestations damage small intestine conditions action common European adder (Vipera berus berus). experiment was conducted 20 non-linear white male rats. During study, rats were divided into two groups — control experimental. Poisoning modeled intraperitoneal injection ED50 dose 1.576 μg/g research group. Histological preparations examined a SEO SСAN light microscope, images processed Vision CCD Camera available image display system computer monitor. It established that venom, toxic substances its destructive-degenerative relief stromal-vascular mucous membrane organ jejunum. Thus, increasing permeability walls vessels microcirculatory channel, thinning complete destruction hemocapillaries, together cytotoxic effect poison erythrocytes, leads formation multiple, hemorrhages hemolysis erythrocytes.